Paramount Capital Structure & History

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Posted on 11th June 2010 by admin in Lindsay Rosenwald Info

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Paramount BioSciences, LLC (“Paramount”) is a primary pharmaceutical drug creation and investment organization with its major focus on the medical and life sciences industries. Having Paramount BioCapital, Inc., a FINRA registered broker-dealer in head of funding and raising capital for Portfolio companies, Paramount BioSciences intensely plays a role in the emergence and progression of revolutionary biotechnologies and life sciences.

Paramount BioScienses’ Plan

Not only can Paramount BioSciences offer specialized services and support, but is additionally involved in new product development, biotech organizations purchase and development. It helps the freshly built businesses in several value-adding methods. They will evaluate system candidates for the companies; generate progression strategies to facilitate the growth process prior to, in the course of, as well as following the configuration of Portfolio Firms. Equally, back-up and know-how is fully recognized by BioSciences as it allows its Portfolio Businesses to access to much more experienced infrastructure than they might have. This gives the business management to pay attention to the medicine candidates’ development as opposed to constructing their very own infrastructure. In lots of ways, this kind of design produced by Paramount’s founder Lindsay Rosenwald gives both expert and “back office” support and limits delays in the advancement process, as well as maximized the earnings for Portfolio companies and the client community.

Right after acceptance and in-licensing, a dedicated supervision crew through the complete creation step generally looks after pharmaceutical candidates. Senior medication production personnel at Paramount BioSciences, including Lindsay Rosenwald, facilitate Portfolio Firms in all of the areas of growth. This includes formulation, medical improvement, toxicology, production, quality assurance, and commercialization. Using their extensive working experience in developing top drug solutions, the Paramount’s team provides solutions for an assortment of therapeutically signs, beginning with inflammation to cardiovascular to oncology to neurology and several other hints. Global network of professionals as well as industry frontrunners within the healthcare and research communities provide guidance throughout the candidates’ creation and approval cycle.

Along with an established track record, Paramount BioSciences facilitates Portfolio Corporations hire employees that will guide the new businesses formed around the new compounds. On the list of recent employees at Portfolio Organizations, there are such executives as the previous CEOs of Roche, Biogen, Johnson&Johnson, Amgen and many more.

More than twenty years of financing and progression of biomedical organizations across a wide range of therapeutic indications, Lindsay Rosenwald is head of Paramount BioSciences’ more than 40 biotech organizations. He forms businesses from the ground-up employing his very own cash and then funds are raised from numerous non-public individuals through Paramount Capital.

Paramount handles such important features as human resources, legal, market analysis, economic capabilities. This assists its Portfolio firms to focus on medical research and generating value for shareholders, licensors and patients.

With such a keen eye for locating and constructing progressive medicines, Paramount BioSciences evaluates the quality and promises of drug candidates around the world, from tiny biotech organizations and instructional centres to substantial prescription companies.

Paramount Approach To Value Generation

What makes Paramount BioSciences stand out is that their infrastructure and outer network enables them to help Paramount Incubated Firms right up until they become self-sufficient. The creation period has been developed by Lindsay Rosenwald in 1999 and may be described in a simple pattern much like this one:

Product Property –> Paramount Preliminary Funding and Development –> Incubation –> Portfolio Company Formation –> Cost Inflection Point

Staff for every single Portfolio Business is appointed in agreement with developmental and financial situations. On average, the majorities of workers at Paramount have at least 15 years of experience in biotechnology or medical care industries driving drug applicants through the regulatory and clinical value string. Their expertise ranges from molecular biology to clinical treatments.

With such a serious practical experience across the pharmaceutical creation enterprise, Lindsay Rosenwald has been able to produce the team with leadership roles within the biotech market with numerous pharmaceutical drug products being sold globally, including Viracept, Neulasta, Rituxan, and Kepivance.

Paramount Departments

Paramount Biosciences

With over forty personnel in eight offices globally, Paramount BioSciences compete and bargain for college and business biotechnology entitlements. It develops and in-licenses compounds for numerous restorative signs – from inflammation and cardiology to neurology and cancer. Lindsay Rosenwald helps create standalone biotech corporations that can attract money and succeed as publicly traded firms

Paramount BioCapital, Inc.

Paramount BioCapital Inc. is a NASD-registered dealer that collects capital for the Portfolio Organizations. It raised in excess of $1 billion and around $200 million in 2009. Using their extensive knowledge in investments purchases such as “PIPEs”, reverse takeovers, self-registrations and private placements, Paramount BioCapital is now the leader in the biotechnology capital sector.

Paramount Development

Lindsay Rosenwald operates directly with Paramount Corporate Development, which is involved with in-licensing and narcotic creation activities. The Business Development group contains twenty market veterans with a huge expertise in all facets of pharmaceutical advancement, including formulation, clinical procedures, manufacturing and commercialization.

Paramount BioCapital Asset Management

Property Management is responsible for acquiring and distributing equities of global healthcare organizations. It has an established hedge fund construction and assets under management in numerous private positioning vehicles.

Paramount Acquisition Company

Paramount Acquisition Company creates special equity finance products that match good sized capitals with late-stage non-public firms. It recently declared a $54 million purchase with Valeritas, which is a health-related device business with its principal FDA-approved insulin pump h-Patch.

Paramount BioSciences Executive Management Staff

Normally, Paramount BioSciences workers have got 15 years of strong knowledge in the medical and regulating functions. Headed by Lindsay Rosenwald, the team members participated in a large number of prescription creation and commercialization projects, including Rituxan, Viracept, Sutent, and Neulasta. Far more than 50 compounds presently go through medical development procedure and the products include medicines across a vast range of indications that include neurological diseases, metabolic problems, contagious diseases and cancer.

Lindsay A. Rosenwald, M.D., is CEO and Chairman at Paramount BioSciences. His considerable expertise within biotechnology, pharmacology and finance made him one of the market leaders in the biotechnology and life sciences industries. With more than 20 years of working experience in building and investing in biotechnology and life science businesses, Dr. Lindsay Rosenwald created and nurtured more than 40 biotech/pharma businesses.

J. Jay Lobell, J.D., is President and Chief Operating Officer at Paramount BioSciences. His prior practical knowledge includes collaboration at Covington & Burling, where he supplied economic, regulatory, business, and litigation assistance to financial institutions, corporations and individuals.

Benefits of Paramount BioSciences Model

What makes Paramount BioSciences a desired acquirer of drug treatments and developer of biotechnologies is that Lindsay Rosenwald’s team of developers along a global business development team that assesses and facilitates unit and marketplace options. The offices of Paramount BioSciences are situated worldwide, which includes New York City, London, Boston, Shanghai, San Diego, North Carolina, Orange County (California)). Promising medication candidates are migrated forward rapidly in the certification process. Reps of all areas in drug creation cycle work together to make sure an agreement to move ahead. The next thing is the generation of unit development plans for the compound and hiring supervision personnel. At this time, the chemical substances are usually transferred to Portfolio Companies with no transition hold-up. The product candidates are supported through the specialized medical and regulatory system.

Paramount BioSciences has proved to rapidly perform deals and initiate development work. Its access to money is a crucial part of any product development. It offers Portfolio organizations with the framework that promotes drug candidate’s acceleration through to marketplace, removing odds of program getting stalled.

Clinical and commercial expertise at the company stage assists Paramount Portfolio companies increase value to in-licensed products.

History regarding Financial Wherewithal

Paramount BioSciences under the direction of Lindsay Rosenwald has produced over $1 billion from outside people in addition to their own investment in Paramount’s portfolio organizations. All companies and specialized medical studies funded through the organization get substantial funding on all stages of the creation cycle.

Linsay Rosenwald has regular and close interaction with the leading US sell-side and buy-side organizations that consist of notable health care individuals, with whom Paramount’s hedge funds put money into the deals not directly involving this company by itself. Paramount’s staff has real-time perception of health-related capital markets, which resulted in over $400 million funds for Portfolio Corporations in 2009 year alone, including $200 million by Paramount. This includes $47 million for Cougar Biosciences along with SG Cowen, $37 million for Ziopharm Oncology, $22 MM for Chelsea Therapeutics and $16 million for Innovive Pharmaceuticals. Many of the top health care funds financed in Paramount in 2010, which continues to be a good indication for the development of medical and life sciences industries.

Lindsay Rosenwald – Paramount Group of Companies

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Posted on 5th April 2010 by admin in Home

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Biotechnology has an increasingly significant impact on a number of life sectors and disciplines. Paramount Group of Companies founded by Lindsay Rosenwald has been working with biotechnology and life sciences for over 20 years. With a global impact on the biotechnology sector, Paramount developed, invested and supported more than 40 life sciences companies over the past 19 years, including 20 in the last 3 years. Current Portfolio Companies have over 40 product candidates that advance through clinical trials. Paramount has also a strong record on scientific, industrial, health and safety issues in biotechnology and pharmacy.

Paramount BioSciences, LLC, founded and managed by Dr. Lindsay A. Rosenwald, is focused on the in-licensing of novel therapeutic and other medical technologies and is involved in corporate companies incubation and governance as well as business development. It extensively supports infrastructure with the experience in licensing, corporate development, clinical operations, and navigation of regulatory pathways. Paramount BioCapital, Inc., a FINRA registered broker-dealer, is involved in raising capital for Paramount’s Portfolio Companies.

Paramount BioSciences Executive Leadership Team

Paramount BioSciences executive team has an extensive collective experience in biotechnology/pharmacy and financial operations.

Lindsay A. Rosenwald, M.D., Chairman and Chief Executive Officer, Founder of Paramount BioSciences. With over 20 years of experience in developing, financing, and investing in biotechnology and life science companies, Dr. Rosenwald has made a powerful contribution to the today’s biotechnology sector. He has also established a charitable foundation called The Rosenwald Foundation Inc., which deals with educational philanthropic research.

J. Jay Lobell, J.D., President and Chief Operating Officer, was a former partner at law firm Covington & Burling, where he provided business, litigation, and regulatory advice to financial institutions, corporations, and individuals.

Russell Ellison, M.D., Executive Vice President, has almost 30 years of senior management pharmaceutical experience in commercialization and drug development. His former positions as the Vice President of Clinical Development at Fibrogen, Inc. and the U.S. Vice President of Medical Affairs and Chief Medical Officer of Sanofi-Synthelabo, USA prove his ability to successfully deal with complex financial and management operations.

Advantages of Paramount BioSciences Model

What makes Paramount BioScienses the preferred acquirer of drugs and development is their flexibility on structure of collaboration and licensing. They have all the assets and skills to rapidly execute, deal and begin development work and access to the capital necessary to develop new products. With a huge clinical and commercial experience and expertise, Paramount’s mission is to maximize value to in-licensed products. Portfolio Companies can be focused on the development of a few key products by providing committed resources (human and financial) as well as a top-tier management expertise, which is focused on a specific product or field.

The structure of Portfolio Company fosters the compound’s progression through to market, eliminating possibilities of the program being shelved.

Financing Models and Related Information

In the past, Paramount Portfolio Companies were publicly traded, via initial public offering, acquisition, reverse merger, or self-registration. The following models are now employed: partnership, merger and acquisition, as well as the Private Company model.

In addition to its own investment in Portfolio Companies, Paramount Group has also raised substantial capital from outside investors. Over the past 60 months more than $400 million was raised for Paramount companies. Such companies include Ziopharm Oncology ($37MM), Cougar Biosciences ($47MM; in conjunction with SG Cowen), and Chelsea Therapeutics ($22MM).

Dr. Lindsay Rosenwald has been able to attract experienced CEO and management staff from such companies and organizations as Serono, Pfizer, Genentech, Johnson & Johnson, Roche, Biogen Idec, Sanofi Aventis, Antigenics, and Celltech. This ensures that Paramount’s commercial and financial aspects always stay on top level.

Clinical Assets of Selected Public and Private Companies Funded by Paramount BioSciences

Keryx Biopharmaceuticals: Phase II Phosphate binder; Phase II drug (Perifosine) for oncology; Phase II drug for oncology (UCN-01)

Javelin Pharmaceuticals: Phase III drug Intranasal Morphine and Intranasal Ketamine for pain relief; Pre-MAA and Phase III Injectable Diclofenac

Cougar Biotechnology: Phase III drug (Abiraterone Acetate) for prostate cancer; Phase I/II drug (Noscapine) for NHL; Phase II drug (Seocalcitol) for prostate cancer

Ziopharm Oncology: Phase II/III drug for myeloma; Phase I/II drug for sarcoma; Phase II drug for breast cancer

Hana Biosciences: Phase II/III drug for hematological malignancies; Phase I drug for EGFR inhibitor rash; Phase II anti-folate for oncology; Phase I/II camptothecin for oncology

Manhattan Pharmaceuticals: Phase II/III drug for Atopic Dermatitis; Phase III sedative buccal spray; Phase III topical head lice preparation

Chelsea Therapeutics: Phase III drug for orthostatic hypotension; Phase II drug for rheumatoid arthritis; IND stage drug for inflammatory conditions

NovaDel Pharma: Buccal spray platform technology; buccal sprays for migraine, anxiety, sleep and multiple other indications under development

Vioquest Pharmaceuticals: Phase II AKT inhibitor for solid tumors and hematological malignancies; Pre-NDA compound for Leishmaniasis; Phase II PTP inhibitor for multiple tumor types; Phase II drug for chemo-induced Hand Foot Syndrome

Tracon Pharmaceuticals, Inc.: TRC-105: Anti-CD105 monoclonal antibody addressing major cancers (prostate, breast and renal cell); TRC-93: Humanized, affinity-matured IgG and retained specificity of murine parental IgM HUI77. This antibody is active in combination with chemotherapy. TRC-102: Small molecule inhibitor of base-excision repair, shown to reverse Temodar® resistance without added toxicity

Alacrity BioSciences, Inc.: ALTY-0501: 0.025% doxycycline inhibits MMP-9 breakdown of corneal barrier. This is a novel mechanism approach to the $500 MM+ dry eye market, which currently offers limited treatment options. ALTY-0601: Small peptide therapeutic with a unique mechanism of action to reduce intraocular pressure (IOP) in patients with ocular hypertension or primary open angle glaucoma

Cutanea Life Sciences, Inc.: CLS001: Omiganan pentahydrochloride is a patented, novel peptide used to treat rosacea that has demonstrated activity against a wide variety of microorganisms, including gram-positive and gram- negative bacteria and fungi. CLS002: Next generation injectible chitosan in soft tissue augmentation. CLS003: Ionic Contra Viral Therapy in development for the treatment of cutaneous warts.

Ventrus BioSciences, Inc.: VEN309: New chemical entity for the topical treatment of hemorrhoids; mechanism of action is to inhibit venous contraction and platelet aggregation, allowing normalization of blood flow. VEN307: Diltiazem cream for anal fissures. VEN308: Phenylephrine gel for fecal incontinence.

Mt Cook Pharma, Inc.: MCP101: TRPV1-agonist; an intravesical treatment for overactive bladder (OAB) and benign prostate hyperplasia (BPH) patients who fail oral medications. MCP202: Oral, first-line delta receptor agonist treatment for OAB and BPH. MCP201: Chemically novel, injectible, mixed opioid receptor agonist for serious pain

Indigo Pharmaceuticals, Inc.: INDI-702: Synthetically derived, oral small molecule for large, chronic, cardiovascular market. Possesses both phosphodiesterase (PDE) inhibitor activity and thromboxane A2 synthetase (TxA2) inhibitor activity and demonstrated increase in peak walking time (p=0.004) compared to placebo at 24 weeks.

Coronado BioSciences, Inc.: CNDO101 (5-imino-3-deoxydoxorubicin): Rationally designed anthracycline analogue with safety advantages – Structural elements responsible for cardio-toxicity has been eliminated. CNDO102 (NK cell activator): Immunotherapy targeting minimal residual disease. The compound has already shown positive efficacy in its ongoing Phase 1 Trial. CNDO103 (Bcl-2 family protein inhibitor platform): Rationally designed, pan-Bcl-2 inhibitor with multiple oncology applications.

Paramount BioSciences

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Posted on 2nd March 2010 by admin in Lindsay Rosenwald Info

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Biotechnology has recently been of substantial importance to  a varied of medical and scientific research disciplines.  Lindsay Rosenwald‘s Paramount Group of Companies has been on the forefront of this new research frontier.  Operating within the fields of biotechnology and research & development of new medicines, treatments, and therapies, Paramount has supported, developed, and financed over 40 companies working within these fields, spanning a period over the last twenty years.  Over 40 prospective medications developed by The Portfolio Companies are moving through clinical trials. Paramount also established a remarkable and consistent history on addressing issues related to scientific questions, industrial concerns, and health and safety metrics in biotechnology and pharmaceutics.

Dr. Linsday A Rosenwald began Paramount by founding Paramount BioSciences, LLC, which focuses on assisting in the licensing of the latest therapies and other pharma technologies.  Paramount BioSciences also works with companies to assist in incubation, corporate governance, and corporate development. Through Paramount BioSciences, and Lindsay Rosenwald’s extensive background in finance and medicine, The Portfolio Group of Companies are provided with support in corporate infrastructure.  Paramount utilizes its functions in licensing, development, clinical operations, and regulatory concerns to assist these companies.  Also of note is Lindsay Rosenwald’s Paramount BioCapital, Inc., a FINRA registered broker-dealer that focuses on raising and generating funding for Paramount’s Portfolio Companies.

The executive management team at Paramount has an inclusive background in biotechnology, pharmaceuticals, and finance.

Lindsay A. Rosenwald, M.D. is the Chairman and CEO as well as the Founder of Paramount BioSciences. Lindsay Rosenwald has over twenty years’ background in the research and financing in biotechnology and life science firms.  Lindsay Rosenwald also founded the nonprofit organization The Rosenwald Foundation Inc., which works to benefit medical, educational, and philanthropic scientific research.

J. Jay Lobell, J.D. is the President and COO.  Arriving at Paramount after serving as a partner at law firm Covington & Burling, J. Jay Lobell’s background gave him useful experience in providing corporate, litigation, and regulatory guidance to financial institutions, businesses, and individuals.

Russell Ellison, M.D. is the Executive Vice President.  Dr. Ellison has almost thirty years’ worth of background in management and pharmaceutics, focusing on commercialization and pharmaceutical research and development. Previously he served as VP of Clinical Development at Fibrogen, Inc., and the US Vice President of Medical Affairs and Chief Medical Officer at Sanofi-Synthelabo, USA.  This experience proves his capabilities in successfully managing complex financial and corporate operations.

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